2013년 10월 29일 화요일

Ilona Warf's blog ::Hill and Doll Doctors Study and Deaths from Lung Cancer since 1980






Ilona Warf's blog ::Hill and Doll Doctors Study and Deaths from Lung Cancer since 1980










Lungs               in               the               human               body               are               two               paired               organs               and               perform               respiration.

Each               lung               is               between               ten               to               twelve               inches               long.

The               lungs               are               separated               by               the               mediastinum,               contains               the               heart,               trachea,               esophagus               and               blood               vessels.

Covering               the               lungs               is               the               pulmonary               pleura               membrane.

Each               day,               approximately               the               average               number               of               breaths               is               23,000,               and               almost               10,000               quarts               of               air               enter               the               lungs.

Air               enters               the               lungs               through               the               nostrils               or               mouth               (Air               contains               several               gases               including               oxygen)               during               inhalation.

Oxygen               is               essential               to               keep               alive               the               cells               in               the               body               by               providing               the               energy               and               growth.

The               oxygen               travels               to               the               tiny               air               sacs               in               the               lungs               called               alveoli.

Each               lung               contains               approximately               300               to               400               million               alveoli.

Surrounding               the               alveoli               are               minute               blood               vessels               (capillaries),               where               oxygen               is               received               and               carbon               dioxide               gas               is               released               (Produced               when               cell               breaks               down               nutrients               as               part               of               the               body's               energy               making               process).

Once               oxygen               enters               the               bloodstream               through               the               capillaries,               the               hemoglobin               in               the               blood               receives               the               oxygen,               and               arteries               carry               the               oxygen               to               sustain               the               life               to               the               tissues               throughout               the               body.

The               carbon               dioxide               is               exhaled               (expiration)               out               of               the               lungs               through               the               mouth               or               nose.

Cancer               that               forms               in               the               tissues               of               the               lung               is               called               lung               cancer,               usually               in               the               cells               lining               the               air               passages.

In               the               United               States,               according               to               the               American               Lung               Association,               lung               cancer               (both               men               and               women)               remains               the               number               one               cancer               killer.

Worldwide               lung               cancer               is               responsible               for               up               to               three               million               deaths               annually.

Two               main               types               of               lung               cancer:               Small               cell               lung               cancer               and               non-small               cell               lung               cancer.

Diagnosing               either               type               of               lung               cancer               is               based               upon               how               the               cells               look               under               a               microscope.

According               to               the               National               Cancer               Institute,               estimated               in               2007:               Diagnose               213,380               of               lung               cancer               (all               types)               and               160,390               deaths.

According               to               Lung               Cancer               Alliance,               seventy               percent               of               lung               cancer               is               diagnosed               in               the               late               stages,               attributing               to               a               high               number               of               deaths.

If               the               tumor               (cancer)               has               spread               (metastasized)               to               other               organs,               ninety-five               percent               of               patients               are               dead               within               five               years.

Unfortunately,               in               many               cases               of               lung               cancer               symptoms               become               noticeable               during               the               advanced               (late)               stage               and               the               result               is               often               fatal.

Symptoms               of               lung               cancer:               Persistent               coughing,               chest               pain,               coughing               up               blood,               shortness               of               breath               (wheezing               or               hoarseness),               swelling               of               the               neck               and               face,               repeated               problems               with               pneumonia               or               bronchitis,               loss               of               appetite               or               weight               loss,               and               fatigue.
               The               number               one               cause               of               lung               cancer               (80               percent               in               women               and               90               percent               in               men)               attributed               to               smoking               (carcinogens).

The               length               of               time               a               person               continues               to               smoke               and               amount               of               the               carcinogen               inhale,               increases               the               person's               chance               of               contracting               lung               cancer.

Twenty-five               percent               of               second               hand               smokers               or               passive               smoking               (other               people's               smoke)               are               diagnosed               with               lung               cancer.

In               1993,               the               Environmental               Protection               Agency               claimed               approximately               3,000               lung               cancer               related               deaths               a               year               were               caused               by               passive               smoking.

Other               factors               attributed               to               the               cause               of               lung               cancer:               Exposure               to               radon               gas,               asbestos,               chemical               (vinyl               chloride,               and               nickel               chromate's)               coal               products,               and               family               history.
               Computerized               chest               scan               (CT)               detects               lung               cancer.

However,               the               test               has               produced               false               alarms,               detecting               both               malignant               and               benign               (non-cancerous)               spots.

Dr.

Simon               D.

Spivack,               pulmonologist               at               Wadsworth               Center,               the               public               health               laboratory               of               the               New               York               State               Department               of               Health               said:               "What               we               found               in               middle               -               age               smokers               is               that               20               to               80               percent               of               these               have               nodules               (Small               masses               of               tissue               in               the               lungs).

But               95               percent               of               the               nodules               are               not               cancer               and               are               not               going               to               be."
               Treatment               for               lung               cancer               depends               on               the               stage               or               development               of               the               cancer,               and               type               of               lung               cancer.

Options               for               treatment               include:               Surgery               to               remove               the               cancer,               use               of               radiation               or               chemotherapy               (medicine)               or               a               combination               of               treatments.

Also,               gene               therapy               is               underway               to               find               a               new               approach               to               cure               lung               cancer.
               A               research               study               analyzed               first               breath               test,               detects               early               stage               of               lung               cancer,               developed               
               by               Menssana               Research               (New               Jersey),               when               it's               most               curable,               published               in               Cancer               Biomakers,               and               funded               by               the               National               Institute               of               Health.

Dr.

Michael               Phillips,               Chief               Executive               Officer               of               Menssana               Research               said:               "We               developed               a               Breathalyzer               that               is               one               billion               times               more               sensitive               than               those               the               police               use               to               measure               alcohol               in               the               breath.

It               detects               around               200               different               chemicals               in               a               person's               breath,               and               some               of               these               chemicals               are               markers               of               cancer               (Test               consists               of               a               color               sensor,               detecting               tiny               chemical               changes               in               the               breath               of               people               with               lung               cancer).

A               breath               test               has               great               advantages               over               most               other               medical               tests               --               it               is               completely               safe,               painless,               and               non               --               invasive.

All               you               have               to               do               is               breathe               gently               into               the               tube               for               two               minutes.

There               are               no               potentially               dangerous               x               --               rays               to               worry               about,               and               it               will               certainly               be               a               lot               less               expensive               than               chest               imaging."               Early               detection               of               lung               cancer               increases               the               percentage               of               lives               saved,               and               the               prognosis               of               early               treatment               is               more               favorable.

The               research               studied               404               smokers               and               ex-smokers               aged               over               sixty.

The               accuracy               of               the               breath               test               predicted               with               almost               the               same               results               as               a               computerized               tomography               or               chest               CT.

The               new               test               can               predict               the               presence               of               lung               cancer               in               three               out               of               four               times.

Regardless               of               age,               gender               or               stage               of               lung               cancer               disease,               results               are               not               affected.

The               breath               test               has               not               yet               been               approved               by               the               Food               and               Drug               Administration               however               maybe               made               available               in               European               Union.

Menssana               researchers               are               developing               breath               tests               to               diagnosis               early               stages               of               other               diseases,               including               pulmonary               tuberculosis,               breast               cancer,               and               ischemic               heart               disease.

Previously,               the               FDA               approved               Menssana               Heartsbreath               test,               determines               if               a               heart               transplant               is               being               rejected               and               potentially               reducing               the               number               of               biopsies,               transplant               patients               often               have               to               endure.
               In               February               2007,               a               study               by               researchers               from               the               H.

Lee               Moffitt               Cancer               Center               &               Research               Institute,               published               in               the               New               England               Journal               of               Medicine,               genetic               test               (Combining               HistoRX               PM-2000(TM)               instrument               and               AQUA(R)               technology)               identifies,               which               early               -               stage               lung               cancer               patients               benefit               from               chemotherapy               (Drugs               used               to               kill               microorganisms               and               cancer               cells               or               cancer               fighting               drugs),               and               those               patients               better               off               without               the               treatment.

The               test               measures               the               activity               of               two               genes:               RRM1               and               ERCC1.

Oncologist               Dr.

Gerold               Bepler               (Research               Institute               in               Tampa               Florida)               said:               "Both               genes               come               into               play               when               we               are               starting               to               treat               people               with               chemotherapy.

If               the               activity               of               these               genes               is               high,               they               are               capable               of               repairing               cells.

That               is               good               because               it               means               that               cancer               is               not               aggressive.

But               (the               genes)               can               counteract               the               effects               of               chemotherapy."               According               to               research,               average               survival               time               for               those               with               high               activity               of               the               RRM1               gene               was               more               then               120               months,               compared               to               54.5               months               with               those               who               showed               low               activity.

According               to               Dr.

Beepler,               the               genetic               test               will               undergo               trial               study               by               the               end               of               2007,               and               results               will               hopefully               be               available               in               two               to               three               years.

Dr.

Adi               F.

Gazdar,               deputy               head               of               the               Harmon               Center               for               Therapeutic               Oncology               Research               at               the               University               of               Texas               Southwestern               Medical               Center               in               Dallas,               recognition               of               the               genetic               test               said:               "It               certainly               could               be               extended               to               many               other               forms               of               cancer."




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