Ilona Warf's blog ::Most common cancers in American women and men
What is the single most common cancer in the entire world? It's also by far the most common skin cancer in the United States. It is basal cell carcinoma, a type of skin cancer. According to the American Cancer Society, 800,000 to 900,000 new cases are diagnosed every year in America. Because basal cell carcinoma is slow growing, it's reasonable to assume that many cases go undiagnosed because the person who has this most common form of cancer can easily die from a car accident, heart disease or diabetes, while all along, this cancer had been slowly growing on some sun-exposed area of their body, unknown to the patient, or maybe known but not minded, brushed off as perhaps a sign of aging skin. A new study links the processes that are involved in the healing of wounds, to a higher risk of basal cell carcinoma. The study comes from the Swedish medical university Karolinska Institutet, and the report is in the Proceedings of the National Academy of Sciences (2011). Mice were used in the study. The number as well as size of basal cell carcinoma tumors can be increased via an active wound healing process. Of course, basal cell carcinoma is the most common cancer in the world simply because so many people spend a lot of time outdoors; basal cell carcinoma is very strongly correlated with sun exposure: about 90 percent of cases. The wound healing process encourages cell proliferation (multiplication), and this may explain the increase in tumor size of this skin cancer. Increase in tumor number is explained by heightened recruitment of cells that have the potential to initiate formation of tumors. "We believe that exposure to UV radiation from the sun together with an active tissue regeneration process is a dangerous combination increasing the risk of developing basal cell carcinoma," states Rune Toftgård, Professor at Karolinska Institutet, and principal study author. Severe sunburn is associated with risk of the deadliest skin cancer, melanoma. But Toftgård says that severe sunburn is a notable risk factor for basal cell carcinoma as well. Does this mean that if you cut yourself, you've just bumped up your risk of basal cell carcinoma? Of course not. Especially since not all kinds of wounds are sufficient for increasing formation of tumors. The tumor enhancing effect comes from damage to deeper portions of the skin. This area of research is relatively new, but these findings certainly can't be ignored. "One may assume that the combination of tissue damage from severe sunburn, and DNA damage or mutations caused by UV radiation has a similar effect," adds Rune Toftgård. In addition to excessive sun exposure, risk factors for the most common cancer in the world, basal cell carcinoma, include exposure to X-rays, coal and industrial tars; fair skin; blonde or red hair; green or blue eyes; and being male. Sources: http://www.sciencedaily.com/releases /2011/02/110215081918.htm http://www.cancercenter.com/basal-cell-carcinoma/basal-cell-carcinoma-risk-factors.cfm |
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